What would you do if the body and brain you rely on suddenly let you down - and would it change the person you are inside? Joe O'Brien is a Boston cop, his physical stamina and methodical mind have seen him through decades policing the city streets, while raising a family with his wife Rosie. When he starts committing uncharacteristic errors - mislaying his police weapon, trouble writing up reports, slurred speech - he attributes them to stress, though some colleagues aren't so sure. Finally, he agrees to see a doctor and is handed a terrifying, unexpected diagnosis Huntington's disease.

Not only is Joe's life set to change forever but each of his four grown-up children has a fifty per cent chance of inheriting the disease. Observing her potential future play out in her father's escalating symptoms, his pretty yoga teacher daughter Katie wrestles with how to make the most of the here and now and how to care for her dad who is, inside, always an O'Bri-en. Inside the O'Briens is a powerfully true and tender elegy to the resilience of the human spirit